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Writer's pictureBrittany Long

Evolution of PBM (Photobiomodulation)

Updated: Dec 8




As AI defines it: Photobiomodulation (PBM) therapy has undergone significant evolution, transitioning from a niche experimental technology to a well-documented, evidence-based treatment modality used across multiple medical disciplines.


Initially discovered in the 1960s through the pioneering work of Endre Mester, who observed the healing effects of low-level laser therapy (LLLT) on wounds, PBM has since expanded in scope and sophistication.


Advances in laser and LED technology have allowed for precise delivery of specific wavelengths and dosages, optimizing cellular responses such as enhanced ATP production, reduced inflammation, and accelerated tissue repair.


Today, PBM is recognized for its versatility, addressing a wide range of conditions including chronic pain, sports injuries, and neuropathy.


Modern devices, like CureWave Lasers, integrate cutting-edge engineering to maximize therapeutic outcomes, making PBM a valuable, non-invasive tool for clinicians seeking effective, drug-free solutions for their patients.


We know light heals. If you believe in the photosynthesis process as you see in plants, this is what we see on a cellular level.

Unfortunately, when PBM was introduced in the late 70's, there were very limited wavelengths to use. The earlier wavelengths were 630nm, 730nm, 770nm, 880nm, 980nm and lastly the 1064NdYAG.

CureWave, using our 30 years in the industry, researched and produced a propriety wavelength, occupying the low peak absorption levels for Melanin, Oxyhemoglobin and Hemoglobin. These low absorption rates reduce scatter and tissue absorption, allowing more light particles deep into the tissue.


See the study: Cedars Sinai (Cedars-Sinai has been involved in research exploring the applications of photobiomodulation (PBM) in medicine, including its effects on reducing complications from cancer treatments. Studies have shown that PBM, using light therapy within the red to near-infrared spectrum, can help mitigate side effects like oral mucositis, radiodermatitis, and other treatment-induced toxicities. For example, PBM has demonstrated efficacy in alleviating oral mucositis in patients undergoing chemotherapy and radiation therapy by promoting tissue healing and reducing inflammation.

The Cedars-Sinai research aligns with broader evidence highlighting PBM's potential in managing conditions like xerostomia (dry mouth), peripheral neuropathy, and lymphedema among cancer patients. These applications are based on its ability to stimulate cellular repair and modulate inflammation without causing thermal damage. This area of study continues to grow, emphasizing the importance of precise dosing and treatment parameters for clinical outcomes【8†source】【9†source】【10†source】.

For more details, you may explore Cedars-Sinai's research initiatives on their website or review systematic reviews discussing PBM's efficacy in oncology care.)


This allows a deep penetration of light particles into the soft tissue creating a positive effect on more cells in a greater area increasing the TZ (Therapeutic Zone).


What some of our medical doctors and users are saying:


"East meets West medicine"

"FINALLY!!!! A lasers clinical results match the theories."

"I never thought a laser could do this without surgical intervention"

"I had my doubts, but with over 1000 patients treated, in fear of using a double negative, the CureWave Laser has never-not worked."

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