Inflammation plays a significant role in numerous chronic illnesses and is a contributing factor in many conditions that can result in death. However, determining the precise number of fatalities directly linked to inflammation is difficult. This process is a key driver in several severe and life-threatening health issues, including:
Cardiovascular diseases (e.g., heart attacks, strokes) – Persistent inflammation is a major factor in atherosclerosis, the buildup of plaques in arteries, which can lead to heart disease and strokes, both of which are among the leading causes of death globally.
Cancer – Prolonged inflammation has been associated with the development of various cancers, such as colorectal, liver, and pancreatic cancer. It can encourage tumor growth, spread, and resistance to treatment.
Respiratory diseases (e.g., chronic obstructive pulmonary disease (COPD), pneumonia) – Inflammatory processes in the lungs may lead to respiratory failure and other complications that increase mortality risk.
Autoimmune disorders (e.g., rheumatoid arthritis, lupus) – Autoimmune-driven chronic inflammation can damage tissues and organs, potentially resulting in organ failure and other severe complications.
Diabetes – Low-grade, ongoing inflammation is a hallmark of type 2 diabetes and contributes to complications like heart disease, kidney failure, and nerve damage.
Overall, inflammation is a critical factor in the global disease burden and a major contributor to premature mortality.
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