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Laser therapy is a medical treatment that uses focused light to stimulate a process called photobiomodulation (PBM means photobiomodulation). During PBM, photons enter the tissue and interact with the cytochrome c complex within mitochondria. This interaction triggers a biological cascade of events that leads to an increase in cellular metabolism, which can decrease pain as well as accelerate the healing process.
Photobiomodulation therapy is defined as a form of light therapy that utilizes non-ionizing light sources, including lasers, light emitting diodes, and/or broadband light, in the visible (400 – 700 nm) and near-infrared (700 – 1100 nm) electromagnetic spectrum. It is a nonthermal process involving endogenous chromophores eliciting photophysical (i.e., linear and nonlinear) and photochemical events at various biological scales. This process results in beneficial therapeutic outcomes including but not limited to the alleviation of pain, immunomodulation, and promotion of wound healing and tissue regeneration. The term photobiomodulation (PBM) therapy is now being used by researchers and practitioners instead of terms such as low level laser therapy (LLLT), cold laser, or laser therapy.
The fundamental principles that underpin photobiomodulation (PBM) therapy, as currently understood in the scientific literature, are relatively straightforward. There is consensus that the application of a therapeutic dose of light to impaired or dysfunctional tissue leads to a cellular response mediated by mitochondrial mechanisms. Studies have shown that these changes can impact pain and inflammation, as well as, tissue repair.
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The primary target for the photobiomodulation process is the Cytochrome C complex, which is found in the inner membrane of the cell mitochondria. Cytochrome C is a vital component of the electron transport chain that drives cellular metabolism.
As light is absorbed by Cytochrome C oxidase (COX), it stimulates the electron transport chain to increase the production of adenosine triphosphate (ATP) within the mitochondria. When tissue is damaged, the production of ATP in the cell is impaired which slows down the metabolism of the cell as a protective mechanism. PBM helps restore the oxidative process which helps restore normal cellular function.
In addition to ATP, laser stimulation also produces free nitric oxide (NO) and modulates reactive oxygen species (ROS). NO is a powerful vasodilator and an important cellular signaling molecule involved in many physiological processes. ROS have been shown to affect many important physiological signaling pathways including the inflammatory response. Together, increased NO and improved ROS levels provide an environment for faster signaling, resulting in decreased inflammation.
PBM helps restore normal cellular function which helps prevent apoptosis (cell death). This helps reduce inflammation, edema, and hastens the tissue repair process.
For PBM to occur, light needs to reach the mitochondria of the damaged target tissue. When laser therapy is applied to the surface of the skin the best results are achieved when a sufficient amount of light (number of photons) reaches the target tissue. There are a number of factors that can help maximize the light that reaches the target tissue, including light wavelength, minimizing unwanted absorption, power and reducing reflections.
High intensity laser therapy (HILT) offers pain relief and tissue repair for inflammation throughout the body, including complex areas like the shoulder. Shoulder pain may stem from issues like inflamed bursae, rotator cuff tears, or tendonitis. HILT penetrates deeply, stimulating increased blood flow, collagen production, and macrophage activity. Infrared light from the laser reaches cellular mitochondria, boosting ATP production and cell metabolism, which accelerates tissue repair and healing.
High-intensity laser therapy (HILT) has recently gained recognition as a valuable addition to wound management therapeutic protocols. Its increasing application in clinical practice serves as an adjunct to traditional therapeutic interventions, reflecting a growing interest in non-invasive treatment options that can enhance patient outcomes.
This study aimed to evaluate the efficacy of HILT specifically for reducing postoperative pain and decreasing infection in patients undergoing spinal cord stimulation implantation. To achieve this, we conducted a retrospective analysis involving 18 patients. Each patient was assessed at two postoperative intervals: on day 5 and on day 10. Patients received the first HILT treatment on day 5 and the second treatment on day 10.
The primary endpoint of our investigation was the change in pain scores, while the secondary endpoint focused on the documentation of postoperative infections. Results demonstrated a significant improvement in pain levels following HILT treatment. The mean pain score before laser was 6.5 (SD 1.1) (Figure 1). Pain after the first treatment was recorded at 3.8 (SD 0.6), which further decreased to a mean score of 2.8 (SD 0.5) after the second treatment, indicating a notable reduction in pain intensity.
In addition to pain relief, we also assessed tissue oxygenation as a potential mechanism through which HILT may exert its effects. The findings revealed an average increase in tissue oxygenation of 17.5% (SD 2.4) following the first treatment and an even greater increase of 18.8% (SD 3.2) after the second treatment (Figure 3). This enhancement in oxygenation could play a critical role in promoting healing and preventing infections.
While the results of this study are promising, they highlight the need for further research to validate these associations and to explore the underlying mechanisms of action for HILT in postoperative care. Future studies should aim to include larger sample sizes and control groups to strengthen the evidence base for the clinical efficacy of high-intensity laser therapy in wound management and postoperative recovery.
Our laser provides a non-contact application that eliminates cross-contamination between patients.
CureWave Laser works at 1280nm deep in the muscloskeleton system bypassing the skin to repair soft tissue. This makes it safe for all skin types and allows the body to naturally heal itself.
This procedure has great benefits without enduring great pain. In fact, when you feel the heat- tell your laser technician to back it up for your optimal healing.
Soft tissue repair reduces inflammation, accelerates the bodies natural healing process and reduces pain. We want to help everyone live our best lives!
Enjoy a non-invasive and non-addictive treatment to reduce pain and inflammation. Whether you're a protective parent, professional athlete, or just a normal adult playing around... We've got you covered with no downtime.
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Our physical therapy benefits of the CureWave Laser are designed to help patients recover from surgeries, injuries and improve their mobility and overall physical wellbeing.
The wide-ranging benefits make PBM a versatile therapy, supporting everything from chronic pain relief to cellular health and athletic recovery, making devices like the CureWave laser an appealing option for users seeking non-invasive, drug-free therapy.
CureWave Laser can provide businesses and their employees with non-invasive treatments that reduce pain and inflammation and aid in soft tissue repair. This helps with healthcare and business solutions, including injury management and prevention.
In this talk, Dr. Hamblin explores PBM's history, its biological mechanisms, and its therapeutic applications. This video provides a foundational look into PBM, perfect for understanding the science behind it
In a detailed conversation, Dr. Hamblin discusses the healing potential of PBM and its effects on cellular health and inflammation. This interview format makes it approachable for those new to PBM concepts
Dr. Hamblin addresses how PBM can help with brain health, particularly focusing on its potential for treating brain disorders by stimulating neural function and reducing inflammation. This lecture is insightful for those interested in PBM’s neurotherapeutic applications
Dr. Hamblin’s keynote speech offers a comprehensive overview of PBM, covering everything from its scientific basis to specific case studies. It’s a more technical talk, ideal for those seeking an in-depth perspective
PBM is widely used for pain management, especially for conditions like arthritis, back pain, and joint disorders. It reduces pain by decreasing inflammation and modulating pain pathways without the need for drugs.
PBM accelerates tissue repair and wound healing by stimulating collagen production and improving circulation, which promotes cell repair and regeneration. This makes it effective for burns, surgical wounds.
PBM therapy helps reduce inflammation by enhancing antioxidant defenses, decreasing oxidative stress, and promoting an anti-inflammatory response. This benefit is especially useful for autoimmune and inflammatory conditions such as rheumatoid arthritis and inflammatory skin disorders.
PBM improves mitochondrial function, resulting in higher production of ATP (adenosine triphosphate), the energy currency of cells. This enhanced cellular energy can improve overall cellular function, aiding recovery and enhancing performance.
PBM can reduce muscle fatigue, improve recovery times, and potentially boost endurance. This is why it is used by athletes to manage sports-related injuries and improve performance and recovery.
Laser therapy has been shown to be effective to help treat acute conditions. Bringing pain under control quickly helps the healing process and usually helps promote better outcomes.
CureWave can be found on the sidelines of many pro, college, and Olympic sports teams across the United States and many parts of Europe and Asia. Laser therapy has been shown to be effective at improving post-activity recovery times and reducing delayed onset muscle soreness (DOMS) (3).
Please reach us at info@curewavelasers.com if you cannot find an answer to your question.
The suffix, –itis comes from the Greek that denotes inflammation. Several studies have shown that laser is an excellent therapy to help address the symptoms related to both osteo and rheumatoid arthritis. While it will not restore damaged cartilage, it can help improve ROM of the affected joints and help reduce pain so that functional levels can be maintained, NSAIDS can be reduced, and in some cases, more invasive procedures can be delayed or prevented.
CureWave lasers work by flooding the tissue with photons, which energizes cells resulting in increased circulation to the injured area and ultimately pain reduction, in a process called photobiomodulation (PBM).
Most clinicians will encourage their patients to receive 2-3 treatments per week as the therapy is initiated. There is a well-documented support that the benefits of laser therapy are cumulative, suggesting that plans for incorporating laser as part of a patient’s plan of care should involve early, frequent treatments that may be administered less frequently as the symptoms resolve.
The term “Cold Laser” is a dated term. It was created to help describe lower power Class 2 and 3 lasers that don’t have power densities (irradiance) sufficiently high enough to create surface heat when applied. Therefore, Class 4 lasers, or Class IV lasers, are not technically “Cold Lasers” since they do create a warming sensation on the skin when applied in most cases.
Since 2015 , the correct term that encompasses all therapy lasers and LEDs is photobiomodulation (PBM). This term describes all light sources that are designed to promote circulation, improve tissue repair, and reduce pain.
Yes, it generally works well with other modalities that are designed to promote tissue repair. Examples might include blood flow restriction and shockwave devices. The mechanisms that are associated with these modalities work well with laser therapy. Generally using modalities that are designed to provide cryotherapy which generally reduce blood flow and promote vasoconstriction are not recommended as adjunctive therapies with laser.
The nature of the condition and the patient’s response to the treatments will play a key role in determining how many treatments will be needed. Most laser therapy plans of care will involve 6-12 treatments, with more treatment needed for longer standing, chronic conditions. Your doctor will develop a treatment plan that is optimal for your condition.
Absolutely! Some of the most consistently reported benefits of laser therapy are related to reduced pain after treatment. Research has shown that PBM can speed up the healing process of certain tissues through increased cellular metabolism. For post-surgical patients, appropriate doses of light energy can be delivered to effectively reduce pain, without negatively impacting the body’s natural healing process.
Yes, laser can be used over metal implants/ hardware. At the irradiance levels used with CureWave's equipment, light will simply bounce off of metal. There will be no heating that takes place at depth when using CureWave's lasers within recommended parameters.
Laser therapy will not limit a patient’s activities. The nature of a specific pathology and the current stage within the healing process will dictate appropriate activity levels. Laser will often reduce pain which will make it easier to perform different activities and will often help restore more normal joint mechanics. That being said, reduced pain should not overshadow the advice of a medical professional that understands how the laser will fit into a rehabilitation protocol when deciding how aggressively to push functional limits.
With CureWave's lasers, treatments are quick usually 3-10 minutes depending on the size, depth, and acuteness of the condition being treated. High-power lasers are able to deliver a lot of energy in a small amount of time, allowing therapeutic dosages to be achieved quickly. For patients and clinicians with packed schedules, fast and effective treatments are a must.
Patients often report improved sensation, including a therapeutic warmth and some analgesia immediately after the treatment. For noticeable changes in symptoms and condition, patients should undergo a series of treatments as the benefits of laser therapy from one treatment to the next are cumulative.
Laser therapy, or photobiomodulation, is the process of photons entering the tissue and interacting with the cytochrome c complex within the cell mitochondria. The result of this interaction, and the point of conducting laser therapy treatments, is the biological cascade of events that leads to an increase in cellular metabolism (promoting tissue healing) and a decrease in pain. Laser therapy is used to treat acute and chronic conditions as well as post-activity recovery. It is also used as another option to prescription drugs, a tool to prolong the need for some surgeries, as well as pre and post-surgery treatment to help control pain.
Class IV laser therapy (now called photobiomodulation) devices were cleared in 2004 by the FDA for the safe and efficacious reduction of pain and increasing micro-circulation. Therapy lasers are safe and effective treatment options to reduce musculoskeletal pain due to injury. The biggest risk to injury during laser therapy treatments is to the eye, which is why certified, protective eyewear is always required during CureWave's treatments.
Laser therapy treatments must be administered directly to skin, as laser light cannot penetrate through layers of clothing. You will feel a soothing warmth as the therapy is administered. Many patients receiving CureWave's Laser treatments report enjoying the experience, especially when a massage-ball treatment head is used to deliver what is often referred to as a “laser massage.”
Patients receiving treatments with higher-power lasers also frequently report a rapid decrease in pain. For someone suffering from chronic pain, this effect can be particularly pronounced. Laser therapy for pain can be a viable treatment.
Based on peer-reviewed literature, there are no known significant side effects from laser therapy for most conditions. Increased blood flow is a positive benefit associated with laser therapy that can cause the skin to get flush and the feeling of warmth. These changes are short-lived, typically lasting for up to a few hours. Improper dosing can lead to increased swelling for acute injuries where there is a lot of inflammation present as well as increased nerve-related pain for certain conditions when irritable nerve tissue is over stimulated. This is usually correctable by adjusting the treatment settings. On these rare occasions, the setbacks usually reverse themselves within 24-36 hours. Understanding proper dosing parameters minimizes this phenomena.
The following are contraindications with laser therapy.
Photobiomodulation therapy can be delivered in either a continuous wave or pulsed mode. Typically, there are two types of pulsing used in therapy lasers—super pulsed or gated.
Super Pulsed. Various claims suggest there are ideal pulsing frequencies; however, there are no published reports that show Super Pulsing is more effective than constant wave forms of light therapy.
Gated. When the laser is used in gated mode, it is cycling its continuous wave power on and off and consequently delivering a lower average output power. In general, the use of pulsing decreases light delivered to the target due to photos being emitted in short bursts with slack periods between.
Continuous Wave. Continuous wave lasers deliver photobiomodulation therapy by having the laser “on” all the time. There is no period where the laser is “off” during the treatment. It is analogous to turning on a light to brighten a room. In most cases, CureWave recommends the use of its equipment in this fashion to maximize energy delivery to the treatment area. This helps promote consistent outcomes by making it easier to correctly dose tissue in less time.